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. 2009 Oct 15;4(10):e7470. doi: 10.1371/journal.pone.0007470

Figure 5. Blocking the ability of DC to acquire cell associated antigens prevents DC infection.

Figure 5

(A) DC were cocultured with infected T cells in the presence of various inhibitors (Cytochalasin D 1 µg/ml; Colchicine 100 µg/ml; AZT 100 µM), post coculture (12 hours) were stained for DC-SIGN and the amount of antigen uptake by DC and percentage of productive infection of DC were evaluated by flow cytometry. The figure is representative of data obtained from one of the five independent donors. Error bars indicate S.D. of the results obtained from triplicate wells from a single donor. (B) Ability of Cytochalasin D to inhibit antigen uptake and productive infection of DC in dose dependent manner. The figure is representative of data obtained from one of four independent experiments. * denotes p<0.5.