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. Author manuscript; available in PMC: 2009 Oct 9.
Published in final edited form as: Small. 2008 Sep;4(9):1307–1312. doi: 10.1002/smll.200701319

Figure 4.

Figure 4

Removable polymer coatings veil nanoparticles in the blood, but are effectively released in tumors. A) Monitoring the release of TAMRA-iron quenching interactions shows that particles with cleavable L-isomer peptides (L-AA) are activated by MMPs, while particles with non-cleavable D-isomer peptides (D-AA) remain intact. B) Representative RGB merge of nanoparticles (green), removable polymer (red), and nuclei (blue) in tumor sections harvested 48 h after injection shows a loss in signal from the removable polymer with cleavable peptides, but not non-cleavable controls. Scale bar is 250 μm. C) The percentage of particles colocalized with the removable polymer in tumor sections harvested 48 h after injection is significantly reduced for the cleavable (L-AA) particle.