Table 3.

Toxicity Studies of Desferrithiocin Analogues in Rodents

Desferrithiocin Analogue	Non-Renal Perfusion Protocol		Renal Perfusion Protocol
	10-d	384 µmol/kg/d poa,b	237 µmol/kg b.i.d. × 7 dc,d
	30-d	Iron-loaded (350 mg Fe/kg)	474 µmol/kg s.i.d. × 7 da
		119 µmol/kg/d pod,e
	10-d	384 µmol/kg/d pod,e	237 µmol/kg b.i.d. × 7 dd,e
	30-d	Unloaded only
		63.3 µmol/kg/d pod,e
	10-d	384 µmiol/kg/d pod,e
	28-d	Iron-loaded (350 mg Fe/kg)
		75 µmol/kg poe
		150 µmol/kg poe	237 µmol/kg b.i.d. × 7 de
		300 µmol/kg poe
	28-d	Unloaded
		75 µmol/kg poe
		150 µmol/kg poe
		300 µmol/kg poe

^aMild Renal Toxicity

^bStudy described in ref 52.

^cSignificant Renal Toxicity

^dStudy described in ref 45.

^eNo Renal Toxicity

^fStudy described in ref 53.