Table 4.
Tissue Distribution of Desferrithiocin Analogues in Rodentsa
| Liver | |||
|---|---|---|---|
| 1 | 2 | 3 | |
| time | (nmol/g wet weight) | (nmol/g wet weight) | (nmol/g wet weight) |
| 1 h (sc) | 80 ±7 | 339 ± 70 | 318 ±46 |
| 1 h (po) | 131 ±9 | 159 ±16 | 234 ± 58 |
| 2 h (sc) | 48 ±20 | 132 ±32 | 193 ±17 |
| 2 h (po) | 73 ±13 | 144 ±18 | 151 ±41 |
| 4 h (sc) | 25 ±4 | 67 ±12 | 168 ±17 |
| 4 h (po) | 44 ±5 | 35 ±14 | 87 ±18 |
| Kidney | |||
| 1 | 2 | 3 | |
| time | (nmol/g wet weight) | (nmol/g wet weight) | (nmol/g wet weight) |
| 1 h (sc) | 179 ±4 | 252 ± 10 | 259 ± 35 |
| 1 h (po) | 208 ± 54 | 114 ± 16 | 150 ± 66 |
| 2 h (sc) | 97 ±50 | 41 ±3 | 145 ± 27 |
| 2 h (po) | 100 ± 21 | 69 ±21 | 48 ±5 |
| 4 h (sc) | 27 ±7 | 34 ±13 | 90 ±8 |
| 4 h (po) | 61 ±9 | 10 ±1 | 15 ±2 |
| Heart | |||
| 1 | 2 | 3 | |
| time | (nmol/g wet weight) | (nmol/g wet weight) | (nmol/g wet weight) |
| 1 h (sc) | 13 ±1 | 35 ±7 | 16 ±1 |
| 1 h (po) | 8 ±1 | 17 ±2 | 9 ±2 |
| 2 h (sc) | 5 ±3 | 9 ±3 | 8 ±1 |
| 2 h (po) | 5 ±1 | 9 ±3 | 4 ±0 |
| 4 h (sc) | not detectable | 5 ±1 | 6 ±1 |
| 4 h (po) | 3 ±0 | not detectable | not detectable |
| Pancreas | |||
| 1 | 2 | 3 | |
| time | (nmol/g wet weight) | (nmol/g wet weight) | (nmol/g wet weight) |
| 1 h (sc) | 28 ±13 | 30 ±5 | 22 ±17 |
| 1 h (po) | 13 + 3 | 25 ±14 | 9 ±5 |
| 2 h (sc) | 6 ±1 | 30 ±25 | 30 ±26 |
| 2h(po) | 9 ±5 | 9 ±2 | 24 ±11 |
| 4 h (sc) | 6 ±3 | 13 ±5 | 12 ±5 |
| 4 h (po) | not detectable | not detectable | 6 ±2 |
| Plasma | |||
| 1 | 2 | 3 | |
| time | (µM) | (µM) | (µM) |
| 1 h (sc) | 34 ±7 | 140 ± 29 | 46 ±3 |
| 1 h (po) | 31 ±11 | 64 ±7 | 26 ±14 |
| 2 h (sc) | 13 ±3 | 16 ±4 | 24 ±5 |
| 2h(po) | 8 ±3 | 32 ±19 | 9 ±3 |
| 4 h (sc) | 2 ±0 | 5 ±3 | 13 ±2 |
| 4 h (po) | 5 ±0 | 2 ±0 | 2 ±0 |
a
The rodents (n = 3/time point) were given a single 300 µmol/kg dose of the chelators sc or po.