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GH exerts direct effects not dependent on IGF-I on body length. Comparison of body length in GH receptor KO (GHR KO), IGF-I KO, IGF-I/GHR double KO (IGF-I + GHR DKO), and wild-type (WT) mice at 130 d of age. The figure is adapted from Table 3 in Lupu et al. (19). Importantly, these data demonstrate that IGF-I and GH exert at least partly independent and additive stimulatory effects on body length. Values are given as percentage of WT and are means ± sem.
