Figure 7.

Reduced spatial learning (A) and memory (B) in mice with liver-specific IGF-I inactivation. Reference memory was measured using the water maze test. During this test, the latency time for the mice to find a platform hidden in water is recorded. The release point, where the mice are let into the water, is randomly shifted. A, Latency time to find the escape platform in 15-month-old mice with liver-specific IGF-I KO (n = 9) and control mice (n = 9) during the first 5 d of the water maze. A two-way ANOVA for repeated measurements was performed, followed by Student Newman Keul’s post hoc test. B, Results of the spatial reference memory (probe) test at day 6. The reference memory (probe) test was performed in the absence of the platform, and percentage of time spent in the trained quadrant was recorded. In B, the given P value is based on an unpaired t test. Values are given as means ± sem. Adapted from Ref. 268.