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. 2009 Jul 9;30(5):494–535. doi: 10.1210/er.2009-0010

Figure 8.

Figure 8

Mice with liver-specific inactivation of IGF-I displayed reduced prostate weight. The clearly decreased prostate weight in mice with liver-specific IGF-I KO associated with decreased mRNA and protein levels of the AR in the ventral prostate. Thus, liver-specific IGF-I deletion reduces the number of ARs expressed in the prostate (right panel). Testosterone from the testicles is then less effective in increasing prostate size. This could, hence, be a mechanism for circulating IGF-I to converge with the androgenic pathway in the regulation of prostate size.