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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: J Biomed Nanotechnol. 2008 Dec 1;4(4):463–468. doi: 10.1166/jbn.2008.011

Figure 4.

Figure 4

Thermal denaturation of free and AuNP-bound HDAC8. AuNP-HDAC8 conjugate was prepared as described in the legend of Fig 3. The time dependant change in free and AuNP-bound enzyme activity was determined upon incubation at 40°C. The fitted lines represent the best fit for exponential decay. Data for free HDAC8 gave single exponential decay with a rate constant of 0.2 ± 0.02 min−1 while AuNP-HDAC8 gave bi-exponential decay with rate constants = 1.2 ± 0.2 and 0.3 ± 0.1 min−1 respectively.