Table 2.
Functional annotation clustering of genes in total and on different branches
| Class | Period of descent* | # Gene | Cluster | Enrichment Score | # Annotations | # Genes |
|---|---|---|---|---|---|---|
| PSG | Total | 94 | Signal | 14.42 | 4 | 53 |
| Extracellular matrix | 6.23 | 9 | 24 | |||
| Collagen | 4.72 | 11 | 9 | |||
| EUT | 62 | Signal | 9.08 | 4 | 35 | |
| ECM-receptor interaction | 5.54 | 9 | 18 | |||
| Collagen | 4.09 | 15 | 10 | |||
| EUA | 20 | Glycoprotein | 8.75 | 3 | 16 | |
| Focal adhesion | 2.95 | 8 | 5 | |||
| Phosphorylation | 2.39 | 3 | 4 | |||
| PRI | 18 | Glycoprotein | 2.63 | 3 | 12 | |
| Macromolecule biosynthesis | 0.72 | 4 | 3 | |||
| Transmembrane | 0.69 | 14 | 9 | |||
| HC | 11 | Localization | 0.62 | 5 | 4 | |
| Cellular physiological process | 0.57 | 4 | 8 | |||
| Intracellular membrane-bound organelle | 0.55 | 5 | 7 | |||
| HUM | 11 | Signal | 0.6 | 7 | 5 | |
| Metabolism | 0.34 | 3 | 5 | |||
| Intracellular membrane-bound organelle | 0.07 | 4 | 3 | |||
| NMH | 54 | Signal | 2.64 | 4 | 19 | |
| Leucine-rich repeat | 1.64 | 4 | 4 | |||
| Leucine-rich repeat | 1.55 | 9 | 4 | |||
| Non_PSG | 128 | Negative regulation of cellular physiological process | 2.24 | 5 | 20 | |
| Transmembrane | 2 | 6 | 41 | |||
| Fibronectin, type III | 1.82 | 3 | 5 | |||
| Total | 222 | Signal | 14.9 | 4 | 85 | |
| Cell communication | 7.23 | 4 | 21 | |||
| Extracellular matrix | 7.22 | 3 | 19 |
*
EUT: Eutheria; EUA: Euarchontoglires; PRI: primates; HC: human-chimpanzee group; H: human terminal (also see Figure 1); 94 unique genes are positively selected and some show this signature on >1 lineage. BOR: not counted because of the small number of genes analyzed. NMH: PSGs that have neither (N) mouse phenotypes (M) nor identified roles in human pregnancy (H) by literature searching.