Table 1.
Electrophysiological effects | Number of neurons tested | Number of significant neuronal responses | Number and percent of neurons showing significant effects |
---|---|---|---|
Effects of control drugs: | |||
1. GABA inhibition | 46 | 285 | 46/46 (100%) |
2. Glutamate excitation | 5 | 21 | 5/5 (100%) |
GABA-dependent effects of insulin: | |||
1. GABA-dependent insulin inhibition | 47 | 148 | 29/47 (62%) |
2. HNMPA blocks GABA-dependent insulin inhibition | 13 | 35 | 13/13 (100%) |
3. Insulin decreases GABA inhibition | 47 | 59 | 18/47 (38%) |
GABA-independent effects of insulin: | |||
1. GABA-independent insulin excitation | 47 | 15 | 3/47 (6%) |
Total number of neurons / microiontophoretic trials | 47 | 563 |