TABLE 2.
Bile acids in brain of control subjects, patients with a peroxisome deficiency disorder (PDD) and patients with a D-bifunctional protein (DBP) deficiency
| Controls |
PBD |
DBP |
|||||
|---|---|---|---|---|---|---|---|
| n = 11 |
n = 8 |
n = 4 |
|||||
| m/z | Mean | Range | Mean | Range | Mean | Range | |
| C29DCA | 507 | 0.01 | 0.00-0.03 | 0.18** | 0.01-0.38 | 0.00 | 0.00-0.00 |
| t-CA | 514 | 0.25 | 0.07-1.18 | 0.22 | 0.05-1.04 | 0.15 | 0.08-0.19 |
| t- CDCA/DCA | 498 | 0.18 | 0.07-0.50 | 0.11 | 0.02-0.21 | 0.15 | 0.08-0.19 |
| g-CA | 464 | 0.16 | 0.03-0.36 | 0.18 | 0.00-0.83 | 0.22 | 0.09-0.37 |
| g-CDCA/DCA | 448 | 0.26 | 0.04-0.43 | 0.14* | 0.00-0.18 | 0.26 | 0.10-0.39 |
| OH-THCA | 465 | 0.05 | 0.00-0.22 | 0.24** | 0.11-0.43 | 0.13 | 0.06-0.22 |
| OH-THCA:1 | 463 | 0.15 | 0.00-0.40 | 0.14 | 0.03-0.38 | 0.15 | 0.00-0.38 |
| THCA | 449 | 0.05 | 0.00-0.23 | 0.50** | 0.07-1.29 | 0.06 | 0.00-0.16 |
| DHCA | 433 | 0.02 | 0.00-0.10 | 0.20* | 0.00-0.53 | 0.06* | 0.04-0.09 |
| CA | 407 | 0.12 | 0.06-0.25 | 0.10 | 0.05-0.27 | 0.11 | 0.08-0.18 |
| CDCA/DCA | 391 | 0.14 | 0.03-0.28 | 0.04** | 0.01-0.09 | 0.09 | 0.05-0.14 |
| Total C27-BA | 0.51 | 0.04-0.98 | 1.36** | 0.40-2.49 | 0.71 | 0.12-1.40 | |
| Total C24-BA | 1.20 | 0.39-2.77 | 0.87 | 0.34-3.06 | 1.04 | 0.49-1.51 | |
| Total BA | 1.71 | 0.78-3.75 | 2.23 | 1.35-4.67 | 1.75 | 0.61-3.02 | |
| C27/C24-BA ratio | 0.44 | 0.05-1.00 | 2.27** | 0.47-3.83 | 0.62 | 0.27-0.94 | |
Bile acids are expressed as nmol/g wet weight. BA, bile acids. CDCA and DCA cannot be distinguished with the method used for bile acid measurement. * P < 0.05; ** P < 0.005 (t-test).