TABLE 1.
24 h Absorption Efficiency (%) |
4 h Intestinal Content (% Initial Dose) |
% Initial Dose in 100 μl Plasma at 4 h |
% Initial Dose in 100 mg Liver at 4 h |
|
---|---|---|---|---|
Mouse Genotype | (n = 7/group) | (n = 8/group) | (n = 8/group) | (n = 8/group) |
WT | 70 ± 11 | 40 ± 7 | 0.13 ± 0.06 | 0.92 ± 0.14 |
SR-BI−/− | 66 ± 14 | 40 ± 6 | 0.18 ± 0.09 | 0.88 ± 0.53 |
CD36−/− | 65 ± 8 | 31 ± 11 | 0.08 ± 0.04 | 0.43 ± 0.22 |
SR-BI−/−/CD36−/− | 67 ± 13 | 34 ± 12 | 0.18 ± 0.10 | 0.67 ± 0.48 |
All values are mean ± SD. No significant differences between mouse genotypes were evident by ANOVA.
The mice weighed 26.4 ± 2.8 g and were aged 3–5 months.