TABLE 5.

Influence of scavenger receptors on intestinal cholesterol absorption in mice fed a HFHC diet for 3 weeks^a

	24 h Absorption Efficiency (%)	4 h Intestinal Content (% Initial Dose)	% Initial Dose in 100 μl Plasma at 4 h	% Initial Dose in 100 mg Liver at 4 h
Mouse Genotype	(n = 12/group)	(n = 8/group)	(n = 8/group)	(n = 8/group)
WT	25 ± 7	19 ± 5	0.05 ± 0.02	0.38 ± 0.12
SR-BI−/−	–b	25 ± 6	0.17 ± 0.07c	0.47 ± 0.21
CD36−/−	23 ± 9	17 ± 6	0.04 ± 0.02	0.34 ± 0.17
SR-BI−/−/CD36−/−	26 ± 8	20 ± 4	0.26 ± 0.09c	0.64 ± 0.31

All values are mean ± SD.

^aThe mice weighed 25.8 ± 3.7 g and were aged 3–5 months.

^bThe cholesterol absorption in SR-BI^−/− mice has been reported previously as being the same as WT mice on aN HFHC diet (31).

^cSignificantly different from WT.