Figure 2. Multiple cytokines are upregulated in the serum and skin of Nlrp3^A350V/+/CreL mice.

(A) Luminex analysis of serum obtained at days 6–8 from WT and Nlrp3^A350V/+/CreL pups, n=10–12 mice, each graph point represents one mouse, mean and SEM are shown. (B) Immunohistochemistry on skin from WT and Nlrp3^A350V/+/CreL pups for IL-1β or IL-6 (red stain), and an isotype control followed by haematoxylin staining. Similar staining was observed on sections from Nlrp3^A350V/+/CreZ (not shown).