Table 3.
Univariate regression analysis (one variable at a time) for relationship between lung function and TLR4 wild-type and polymorphic groups
| Lung Function |
Model I FEV1 |
Model II FVC |
Model III FEV1/FVC |
Model IV FEF25_75 |
| Variable | Parameter Estimate (SE) | Parameter Estimate (SE) | Parameter Estimate (SE) | Parameter Estimate (SE) |
| Age, yrs | -0.033 (0.001)*** | -0.036 (0.001)*** | -0.001 (0.000)*** | -0.041 (0.002)*** |
| BMI‡ (reference is normal) | ||||
| Overweight | 0.074 (0.055) | 0.134 (0.067)* | -0.010 (0.004)* | 0.057 (0.075) |
| Obese | -0.060 (0.057) | -0.106 (0.069) | 0.003 (0.004) | 0.096 (0.077) |
| Smoking status (reference is never smoker) | ||||
| Ever smoker | -0.032 (0.044) | 0.012 (0.054) | -0.011 (0.003)** | -0.151 (0.060)* |
| Sex (reference is female) | ||||
| Male | 1.031 (0.037)*** | 1.336 (0.044)*** | -0.011 (0.003)** | 0.934 (0.056)*** |
| TLR4299 (reference is wild-type) | ||||
| polymorphic groups | 0.134 (0.064)* | 0.185 (0.078)* | -0.002 (0.004) | 0.091 (0.088) |
| Grain Dust (reference is not exposed) | ||||
| Exposed | 0.299 (0.045)*** | 0.426 (0.054)*** | -0.011 (0.003)** | 0.214 (0.061)** |
| Household Smoking (Reference is No) | ||||
| Yes | 0.021 (0.069) | 0.001 (0.083) | 0.004 (0.005) | 0.037 (0.093) |
*** p < 0.001; ** p < 0.01; * p < 0.05
‡Normal: <25; Overweight: 25-30; Obese: >30