. 2009 Sep 21;9:46. doi: 10.1186/1471-2466-9-46

Table 4.

Multiple regression analysis for relationship between lung function and TLR4 wild-type and polymorphic groups, adjusting for age, BMI, sex and smoking

Lung Function	FEV₁	FVC	FEV1/FVC	FEF25_75
Variable	Parameter Estimate (SE)	Parameter Estimate (SE)	Parameter Estimate (SE)	Parameter Estimate (SE)

Age, yrs	-0.033 (0.001)***	-0.036 (0.001)***	-0.001 (0.000)***	-0.041 (0.002)***
BMI (reference is normal: <25)
Overweight (BMI: 25-30)	0.019 (0.035)	0.026 (0.042)	-0.00002 (0.004)	0.065 (0.064)
Obese (BMI: >30)	-0.057 (0.035)	-0.145 (0.043)**	0.015 (0.004)***	0.232(0.065)***
Smoking status (reference is never smoker)
Ever smoker	-0.074 (0.027)**	-0.056 (0.033)	-0.007 (0.003)*	-0.176 (0.047)***
Sex (reference is female)
Male	1.059 (0.028)***	1.367 (0.034)***	-0.010 (0.003)**	0.959(0.048)***
TLR4299 (reference is wild-type)
polymorphic groups	-0.020 (0.039)	0.003 (0.048)	0.007 (0.009)	0.062 (0.135)
Interactions
BMI and TLR4299 (reference is < 25 BMI and Wild type)
25-30 BMI group and polymorphic group			-0.008 (0.011)	0.040 (0.172)
>30 BMI group and polymorphic group			-0.021 (0.011)^#	-0.432 (0.175)*

*** p < 0.001; ** p < 0.01; * p < 0.05 ^#p < 0.10