The inter-follicular dermal macroenvironment includes dermis, subcutaneous fat and adjacent follicles. Anagen stimulating (black and green) or inhibitory (red) activities are depicted with colored arrows. Follicles are in different stages: A, refractory telogen; B, competent telogen; C, propagating anagen; D, autonomous anagen follicles. Blue circle in A, intra-follicular micro-environment. Color codes are similar to Fig. 12. From Plikus et al., 2008.