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. 2009 Sep 22;10:305. doi: 10.1186/1471-2105-10-305

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Copyright © 2009 Knott et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Validation. (A) 251 origins are found to fire in this BrdU-IP-chip analysis as compared to the 290 identified in [30] and 141 in [29]. Of the 251 origins identified here 224 (89 percent) were identified in at least one of the other two studies. (B) 142 WT peak heights (calculated here) plotted against their times of replication (as calculated in [31]). The Spearman Rank Correlation between peak heights and time of replication was found to be -0.78. (C) A comparison of WT and rpd3Δ peak heights shows significant increases (empirical Bayes t-test, p ≤ 0.001) in rpd3Δ heights at origins ARS603, ARS1413 and ARS501 while the same analysis shows no change (empirical Bayes t-test, p > 0.001) at origins ARS607 and ARS1.