Table 3.
Performance of LASSO mortality model by sex, cause of death, and time since blood draw
| Subset | At risk | Deaths | IQRR | Z | P-value | Median survival 1st quartile | Median survival 4th quartile |
|---|---|---|---|---|---|---|---|
| All | 104 | 72 | 2.35 | 5.49 | 4.0E−08 | 89.3 | 83.8 |
| Males | 52 | 40 | 2.73 | 3.76 | 0.00017 | 90.5 | 81.7 |
| Females | 52 | 32 | 2.31 | 3.99 | 6.6E−05 | 88.8 | 84.7 |
| Cause of death | |||||||
| Heart | 104 | 19 | 2.17 | 2.65 | 0.0080 | ||
| Cancer | 104 | 14 | 2.37 | 2.14 | 0.032 | ||
| Stroke | 104 | 11 | 3.73 | 3.54 | 0.00040 | ||
| Diabetes | 104 | 5 | 7.72 | 3.21 | 0.0013 | ||
| Inf/Pneu | 104 | 5 | 3.48 | 2.49 | 0.013 | ||
| Cognitive | 104 | 10 | 2.57 | 2.12 | 0.034 | ||
| Years after blood draw | |||||||
| 1 | 103 | 71 | 2.35 | 5.46 | 4.8E−08 | 89.1 | 82.6 |
| 3 | 95 | 64 | 2.27 | 4.75 | 2.0E−06 | 89.4 | 84.6 |
| 5 | 88 | 57 | 2.53 | 4.27 | 2.0E−05 | 90.4 | 85.2 |
| 10 | 72 | 41 | 2.41 | 3.30 | 0.00097 | 91.5 | 88.1 |
IQRR, relative risk comparing the 75th percentile of estimated risk (0.21) to the 25th percentile (−0.03), adjusted for actual age and sex; median survival 1st quartile, estimated median survival for subjects at the 25th percentile of estimated risk (adjusted for age and sex); median survival 4th quartile, estimated median survival for subjects at the 75th percentile of estimated risk (adjusted for age and sex).