Table 1.

ABCA1- and ABCG1- dependent cholesterol efflux was determined as outlined in the methods. Efflux experiments were performed at 37 °C by incubating cells with serum (diluted to 2.5%) from patients pre-AP, AP1- d and AP- 5d for 16 h in DMEM containing 0.2% BSA. Values represent the average of triplicate determinations of n=6–8 patients. Results are presented as a percentage of pre-AP serum efflux. ApoA-I was measured using an automated turbidimetric immunoassay (Mayo Medical Laboratories, Rochester, MN). HDL was quantitated using a commercial kit.

	pre-AP	AP- 1d	AP- 5d
ABCA1-efflux (% of pre-AP)	100	82.5 ± 3.5	99.2 ± 2.9
ABCG1- efflux (% of pre-AP)	100	70.0 ± 14.3a	108.5 ± 16.7
plasma apoA-I (μg/ml)	1161.7 ± 117.6b	545.0 ± 62.4	785.0 ± 36.6
plasma HDL-C (μg/ml)	389.7 ± 60.5	196.6 ± 39.1c	238.7 ± 27.9

^ap<0.05 vs pre-AP and AP- 5d;

^bp<0.001 vs AP- 1d and AP- 5d;

^cp < 0.5 versus pre-AP.