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. Author manuscript; available in PMC: 2010 Oct 15.
Published in final edited form as: Org Lett. 2009 Oct 15;11(20):4520–4523. doi: 10.1021/ol9016595

Scheme 1.

Scheme 1

Structure of halichondrin B and C-C bond-forming sites in the synthesis of C14-C26 building block. Panel I: the first generation synthesis using three C-C bond-forming reactions indicated.1 Panel II: the new synthesis using three catalytic asymmetric Cr-mediated coupling reactions indicated.5