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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Cancer Res. 2009 Sep 29;69(19):7644–7652. doi: 10.1158/0008-5472.CAN-09-0823

Figure 3. PI3K/mTOR blockade sensitizes NSCLC cells to the pro-apoptotic effects of IR.

Figure 3

A. Graph illustrating clonogenic survival assays of H460 and H23 cells treated as indicated. Colony number was calculated from three replicate plates of three independent experiments; bars, SD. B. WB analysis of H23 and H460 cells treated as indicated. Note that treatment with BEZ235 and IR leads to a significant increase of cleaved PARP (89kDa). C. Cell cycle analysis of H23 and H460 cells treated as indicated. The percentage of cells in each phase of the cell cycle is indicated. Note significant increase of the percentage of sub G1 cells 24h after treatment with BEZ235 in combination with IR. Graph on the right indicates percentage of cells in sub G1. *, P<0.05; **, P<0.01 between untreated and IR+BEZ235.