Table 1:

Effect of dosing vehicle on toxicokinetic parameters of 25 μg FLA/kg body wt. orally administered to F-344 male rats.

Parameter	Peanut oil	Cod liver oil	Tricaprylin	2% Alkamuls	Tween 80/isotonic saline (1:5)
Area under curve (AUC; mg/ml/hr)	0.013 ± 0.005	0.018 ± 0.004*	0.010 ± 0.005	0.005± 0.002*	0.003± 0.0003*
Biological half-life (t1/2; hrs)	2.5 ± 0.027	3.0 ± 0.035	2.1 ± 0.028	1.5 ± 0.020*	0.7 ± 0.019*
Volume of distribution (Vd; ml/kg)	0.12 ± 0.016	0.19 ± 0.013	0.10 ± 0.014	0.07 ± 0.011*	0.03± 0.010*
Clearance (Cl; ml/hr/kg)	0.013 ± 0.008	0.022 ± 0.003*	0.009 ± 0.001	0.005 ± 0.004*	0.002 ± 0.004*
Mean residence time (MRT; hrs) (MRT; hrs)	2.5 ± 0.015	3.7 ± 0.015*	2.3± 0.019	2.0 ± 0.017*	1.4 ± 0.015*
Elimination rate (Kd; hrs)	0.055 ± 0.006	0.08 ± 0.002	0.04 ± 0.003	0.04 ± 0.006	0.01 ± 0.0002

Values represent mean ± standard error (n = 6).

^*denote statistical significance (p < 0.05) of toxicokinetic parameter values compared to peanut oil vehicle (control).