Table 2:

Effect of dosing vehicle on toxicokinetic parameters of 50 μg FLA/kg body wt. orally administered to F-344 male rats.

Parameter	Peanut oil	Cod liver oil	Tricaprylin	2% Alkamuls	Tween 80/isotonic saline (1:5)
Area under curve (AUC; mg/ml/hr)	0.018 ± 0.002	0.025 ± 0.004*	0.015 ± 0.005	0.009± 0.003*	0.005± 0.0003*
Biological half-life (t1/2; hrs)	3.2 ± 0.031	3.7 ± 0.035	2.8 ± 0.028	2.1 ± 0.020*	1.3 ± 0.015*
Volume of distribution (Vd; ml/kg)	0.22 ± 0.016	0.27 ± 0.014	0.19 ± 0.014	0.13 ± 0.011*	0.09± 0.010*
Clearance (Cl; ml/hr/kg)	0.020 ± 0.008	0.031 ± 0.002*	0.013 ± 0.004	0.009 ± 0.004*	0.006 ± 0.004*
Mean residence time (MRT; hrs) (MRT; hrs)	5.5 ± 0.015	6.5 ± 0.013*	4.8± 0.015	3.8 ± 0.017*	2.6 ± 0.015*
Elimination rate (Kd; hrs)	0.095 ± 0.006	0.11 ± 0.002	0.08 ± 0.003	0.07 ± 0.006	0.03 ± 0.002

Values represent mean ± standard error (n = 6).

^*denote statistical significance (p < 0.05) of toxicokinetic parameter values compared to peanut oil vehicle (control).