Table 3.
In Vitro Growth Inhibitory Effects of Compounds 8a-8j with Different “C” Rings against the Proliferation of Melanoma (A 375, B16-F1) and Prostate Cancer Cells (DU145, PC-3, LNCaP, PPC-1).
| Compounds 8 | C Ring | IC50 ± SEM (μM) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| B16-F1 | A375 | DU 145 | PC-3 | LNCaP | PPC-1 | ||||
 |
8a | Ph | >100 | >100 | >20 | >20 | >20 | >20 | |
| 8b | 4-Methoxy-Ph | >100 | >100 | >20 | >20 | >20 | >20 | ||
| 8c | 3-Methoxy-Ph | >100 | >100 | >20 | >20 | >20 | >20 | ||
| 8d | 2-Methoxy-Ph | 59.4 ± 21.2 | 70.3 ± 32.5 | >20 | >20 | >20 | >20 | ||
| 8e | 3, 4-Dimethoxy-Ph | >100 | >100 | >20 | >20 | >20 | >20 | ||
| 8f | 3,4,5-Trimethoxy-Ph | 0.055 ± 0.005 | 0.028 ± 0.005 | 0.071 ± 0.004 | 0.021 ± 0.001 | 0.028 ± 0.004 | 0.043 ± 0.005 | ||
| 8g | 3, 5-Dimethoxy-Ph | 0.350 ± 0.2 | 0.170 ± 0.1 | 0.424 ± 0.098 | 0.301 ± 0.030 | 0.323 ± 0.041 | 0.242 ± 0.014 | ||
| 8h | 2-Fluoro-Ph | >100 | >100 | >20 | >20 | >20 | >20 | ||
| 8j | Hexadecyla | 18.6±17.5 | 16.0 ± 15.2 | >20 | >20 | >20 | >20 | ||
a
Compound 8j has a lipid chain at “C” ring position.