Table 2. Association of DCLK1 markers to IQ scores in the three samples.
NCNG | LBC1921 | LBC1936 | ||||||||||
IQ | IQ79 | IQ79rIQ11 | IQ11 | IQ70 | ||||||||
Markers | Code | Localisation | LR | HTR3 | LR | HTR3 | LR | HTR3 | LR | HTR3 | LR | HTR3 |
rs10492555 | m5′.1 | 5′ | - | 0.034 | - | - | - | - | - | - | - | - |
rs9315390 | m5′.2 | 5′ | - | 0.010 | - | - | - | - | - | - | - | - |
rs9315383 | m3.1 | Intron 3 | 0.005 | - | - | - | - | - | - | - | - | - |
rs7334245 | m3.2 | Intron 3 | - | - | - | - | - | - | - | - | - | - |
rs7989807 | m3.3 | Intron 3 | - | - | - | - | - | - | - | - | - | - |
rs7323560 | m3.4 | Intron 3 | - | - | - | - | - | - | - | - | - | - |
rs7989245 | m4 | Intron 4 | - | - | - | - | - | - | - | - | - | - |
rs10507435 | m5.1 | Intron 5 | 0.027 | - | - | - | - | - | - | - | - | 0.0092 |
rs943220 | m5.2 | Intron 5 | - | - | - | - | - | - | - | - | - | - |
rs4391923 | m5.3 | Intron 5 | - | - | - | - | - | - | - | 0.010 | - | |
rs2296645 | m11 | Exon 11 | - | 0.046 | - | - | - | - | - | 0.045 | - | |
rs1926467 | m15 | Intron 15 | 0.025 | - | - | - | 0.014 | - | 0.023 | - | - | - |
rs12430800 | m19.1 | Intron 19 | - | 0.019 | 0.0042 | 0.022 | 0.0019 | 0.00034 | - | - | - | - |
rs4591003 | m19.2 | Intron 19 | - | - | - | 0.014 | 0.039 | - | 0.015 | - | - | - |
rs9545332 | m19.3 | Intron 19 | - | - | - | - | - | 0.023 | - | - | - | |
rs872060 | m3′ | 3′ | - | - | 0.026 | - | 0.038 | - | - | - | - | - |
Both single marker linear regression (LR) and haplotype trend regression of 3-markers sliding windows analyses (HTR3) are presented. Only p-values below 0.05 are displayed. All analyses were performed using sex and age as covariates. The NCNG was assessed with the Wechsler Abbreviated Scale of Intelligence [27]. LBC1921 and LBC1936 were assessed for IQ with the Moray House Test (see SOM). For LBC1921, no association below p = 0.05 was observed for IQ11. In the LBC samples, all regression analyses were performed both with and without IQ11 as a covariate. P-values highlighted in bold are resisting a 10,000 permutations testing.