Table 1.
Summary of chromosome 6 alteration in astrocytic tumours
| n | MSA | Normal | ND | Any copy number changes |
Monosomy | Trisomy | Partial copy number changes | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||||||||
| n | (%) | Total | 6p loss |
6p gain |
6q loss |
6q gain |
Amp | |||||||
| All cases |
||||||||||||||
| A | 10 | 2 | 8 | 0 | 2 | na | 0 | 0 | 2 | 0 | 1 | 2 | 0 | 0 |
| AA | 30 | 14 | 4 | 1 | 25 | na | 4 | 1 | 20 | 4 | 6 | 16 | 3 | 1 |
| GB | 64 | 38 | 15 | 2 | 47 | na | 9 | 0 | 38 | 7 | 3 | 35 | 5 | 1 |
| Total | 104 | 54 | 27 | 3 | 74 | na | 13 | 1 | 60 | 11 | 10 | 53 | 8 | 2 |
| Unselected series |
||||||||||||||
| A | 8 | 0 | 8 | 0 | 0 | 0% | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| AA | 16 | 0 | 4 | 0 | 12 | 75% | 2 | 1 | 9 | 4 | 3 | 5 | 1 | 0 |
| GB | 26 | 0 | 15 | 0 | 11 | 42% | 2 | 0 | 9 | 4 | 0 | 7 | 0 | 1 |
| Total | 50 | 0 | 27 | 0 | 23 | 46% | 4 | 1 | 18 | 8 | 3 | 12 | 1 | 1 |
MSA, cases examined by microsatellite analysis and selected based on their findings. ND, not determined (see Results). Amp, amplification. na, not applicable because some tumours were selected based on the previously known chromosome 6 alterations.