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. 2009 Oct 23;5(10):e1000634. doi: 10.1371/journal.ppat.1000634

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Table of allele-specific differences located on the surface of RRV VP7. The VP7 type corresponds to the alleles defined in Figure 2 (orange, green, red, and cyan) or to reference G3 RV strains (RRV, Wi68, RV3 and P). The amino acid at each position is listed to the right of the VP7 type. Numbering is based on RRV VP7 (GenBank# AF295303). (B) Three-dimensional location of surface-exposed allele-specific differences. The left image shows the architecture of a RV virion (modified with permission from B.V.V. Prasad) and the positions of VP7 and VP4. The right image shows a surface representation of the VP7 trimer crystal structure (PDB# 3FMG). Residues comprising the putative neutralization domains of VP7 are listed in Table S3 and have been colored as follows: pink (7-1A), salmon (7-1B), and purple (7-2). Allele-specific differences are shown in yellow and are labeled for a single monomer of the trimer.