TABLE 1.
Unconstrained 2-Tissue-Compartment Model Using 2 Hours of Data
| Rate constant |
Distribution volume |
Goodness of fit |
||||||
|---|---|---|---|---|---|---|---|---|
| Region | K1 (mL · cm−3 · min−1) | k2 (min−1) | k3 (min−1) | k4 (min−1) | BPND (unitless) | VT (mL · cm−3) | AIC | MSC |
| Frontal cortex | 0.29 ± 0.06 (2.3 ± 0.7) | 0.08 ± 0.05 (11.3 ± 2.1) | 0.105 ± 0.05 (11.4 ± 2.6) | 0.021 ± 0.003 (4.9 ± 1.1) | 5.3 ± 3.5 (10.8 ± 2) | 22.7 ± 2.3 (1.4 ± 0.2) | 116 ± 30 | 4.6 ± 0.4 |
| Parietal cortex | 0.25 ± 0.04 (2.0 ± 0.4) | 0.08 ± 0.05 (9.7 ± 2.8) | 0.101 ± 0.05 (10.2 ± 3.9) | 0.020 ± 0.003 (4.8 ± 1.4) | 5.4 ± 3.4 (9.2 ± 3.1) | 20.2 ± 1.5 (1.6 ± 0.4) | 109 ± 27 | 4.6 ± 0.4 |
| Occipital cortex | 0.26 ± 0.04 (2.4 ± 0.4) | 0.09 ± 0.05 (11.0 ± 3.0) | 0.104 ± 0.05 (11.4 ± 2.4) | 0.020 ± 0.003 (5.0 ± 1.5) | 5.5 ± 3.4 (10.2 ± 2.1) | 19.3 ± 2.2 (1.6 ± 0.4) | 115 ± 25 | 4.4 ± 0.4 |
| Temporal cortex* | 0.28 ± 0.05 (2.0 ± 0.5) | 0.07 ± 0.05 (11.5 ± 2.3) | 0.107 ± 0.06 (11.8 ± 2.7) | 0.021 ± 0.003 (5.1 ± 1.2) | 5.5 ± 3.8 (11.2 ± 2.3) | 25.8 ± 2.4 (1.5 ± 0.2) | 110 ± 28 | 4.7 ± 0.5 |
| Medial temporal cortex | 0.23 ± 0.05 (2.1 ± 0.7) | 0.07 ± 0.04 (10.2 ± 3.2) | 0.093 ± 0.04 (10.0 ± 2.1) | 0.018 ± 0.002 (4.7 ± 0.9) | 5.3 ± 2.9 (9.3 ± 3.0) | 19.7 ± 3.2 (1.6 ± 0.2) | 98 ± 17 | 4.6 ± 0.4 |
| Caudate | 0.27 ± 0.07 (2.1 ± 0.5) | 0.07 ± 0.04 (11.1 ± 3.4) | 0.091 ± 0.04 (11.5 ± 3.4) | 0.021 ± 0.002 (4.8 ± 1.0) | 4.6 ± 2.5 (10.7 ± 3.7) | 21.7 ± 3.9 (1.5 ± 0.3) | 110 ± 26 | 4.7 ± 0.4 |
| Putamen | 0.32 ± 0.08 (2.1 ± 0.5) | 0.08 ± 0.03 (9.6 ± 2.2) | 0.085 ± 0.03 (10.1 ± 2.1) | 0.021 ± 0.002 (4.4 ± 0.6) | 4.3 ± 2.0 (9.0 ± 2.3) | 22.3 ± 4.3 (1.5 ± 0.2) | 123 ± 23 | 4.7 ± 0.3 |
| Cingulate | 0.27 ± 0.07 (2.2 ± 0.9) | 0.07 ± 0.05 (10.7 ± 2.4) | 0.091 ± 0.05 (11.6 ± 2.5) | 0.021 ± 0.002 (5.3 ± 0.9) | 4.5 ± 3.0 (10.4 ± 2.3) | 22.7 ± 2.5 (1.6 ± 0.2) | 112 ± 27 | 4.7 ± 0.4 |
| Thalamus | 0.31 ± 0.08 (2.0 ± 0.3) | 0.10 ± 0.05 (7.0 ± 0.7) | 0.072 ± 0.03 (7.7 ± 1.0) | 0.018 ± 0.002 (4.2 ± 0.5) | 4.0 ± 1.7 (6.0 ± 0.6) | 15.8 ± 2.9 (1.5 ± 0.1) | 120 ± 22 | 4.8 ± 0.2 |
| Cerebellum | 0.28 ± 0.05 (2.4 ± 0.4) | 0.12 ± 0.04 (6.9 ± 0.8) | 0.074 ± 0.02 (6.6 ± 0.9) | 0.014 ± 0.001 (4.4 ± 0.6) | 5.2 ± 1.5 (5.2 ± 0.6) | 14.2 ± 1.6 (2.0 ± 0.2) | 115 ± 25 | 4.4 ± 0.3 |
*
Includes all of temporal lobe except medial temporal cortex.
Values are mean ± SD from 7 healthy subjects and were calculated from 2-h brain and plasma data. For each brain region, identifiability is listed in parentheses and expressed as percentage of variable itself.