Table 1.
Reference | Cause of MYC deregulation | Increased MYC | Number of cases | Rate (%) of cases with MYC deregulation |
[38] | Overexpression | Protein | 88 | 55 |
[39] | Overexpression | Protein | 213 | 23.5 |
[40] | Amplification/Overexpression | DNA/Protein | 31/51 | 12.9/41.2 |
[41] | Overexpression | RNA | 51 | 68.6 |
[42] | Amplification | DNA | 23 | 26 |
[43] | Amplification | DNA | 21 | 48 |
[44] | Amplification | Protein | 154 | 15.5 |
[45] | Overexpression | Protein | 48 advanced/28 early | 50/42 |
[46] | Overexpression | Protein | 98 advanced/45 early | 28/34 |
[47] | Amplification | DNA | 51 | 24 |
[48] | Amplification | DNA | 10 | 30 |
[49] | Overexpression | Protein | 42 advanced/77 early | 40.5/15.6 |
[50] | Amplification/Overexpression | DNA/Protein | 23 | 26 |
[51] | Overexpression | Protein | 30 advanced/ 6 early | 63.3/50 |
[52] | Overexpression | Protein | 35 advanced/74 early | 34/16 |
[53] | Overexpression | Protein | 84 | 88.1 |
[54] | Overexpression | Protein | 63 | 52.4 |
[55] | Overexpression | Protein | 65 | 61.5 |
[56] | Amplification | DNA/Protein | 11 | 100 |
[37] | Amplification/Overexpression | DNA/Protein | 7 | 100 |
[57] | Overexpression | Protein | 204 | 43 |
[58] | Overexpression | Protein | 71 | 42.3 |
[59] | Amplification/Overexpression | DNA/Protein | 5 early | 100 |