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. Author manuscript; available in PMC: 2009 Oct 12.

Published in final edited form as: Biochem Biophys Res Commun. 2008 Apr 25;371(4):644–648. doi: 10.1016/j.bbrc.2008.04.080

FIG. 3 — A. 2-APB inhibits NFAT activation. 2-APB, the known IP3R inhibitor, inhibits NFAT activity in all groups (with or without murine SH3BP2 and/or sRANKL) in RAW 264.7 cells (# indicates p<0.02 and ## indicates p<0.0001).

B. TRAP staining and TRAP activity were nearly eliminated by 2-APB. 2-APB inhibited TRAP activity in RAW 264.7 cells after one week of culture indicating an inhibition of osteoclastogenesis. # indicates p<0.02 and ## indicates p<0.005.

FIG. 3 — A. 2-APB inhibits NFAT activation. 2-APB, the known IP3R inhibitor, inhibits NFAT activity in all groups (with or without murine SH3BP2 and/or sRANKL) in RAW 264.7 cells (# indicates p<0.02 and ## indicates p<0.0001).

B. TRAP staining and TRAP activity were nearly eliminated by 2-APB. 2-APB inhibited TRAP activity in RAW 264.7 cells after one week of culture indicating an inhibition of osteoclastogenesis. # indicates p<0.02 and ## indicates p<0.005.