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Reciprocal MTL-medial parietal memory network. MTL is hyperactivated in very mildly impaired MCI individuals compared to controls (top), while precuneus is hyper-deactivated (middle). Across a group including cognitively intact, MCI, and AD individuals, the degree of hippocampal activation (x axis) correlates with the degree of precuneus deactivation (y axis) (Celone et al., 2006) (p<0.0001).
