Table 1. Neuromuscular and Sensory Data.
Data are presented as mean plus or minus standard deviation (n=5 for each sex-genotype) Statistical significance is delineated as follows: * p < 0.05, male vs. female, ** p < 0.05, Col9a1-/- vs. wildtype, and *** p < 0.001, Col9a1-/- vs. wildtype.
| Male | Female | |||
|---|---|---|---|---|
| Wildtype | Col9a1-/- | Wildtype | Col9a1-/- | |
| Weight (grams) | 33.4 ± 2.2* | 35.5 ± 4.6* | 28.4 ± 3.0 | 26.3 ± 1.3 |
| Righting (median score) | Normal | Impaired*** | Normal | Delay*** |
| Wire hang (sec) | 42.8 ± 4.9 | 11.4 ± 3.5*** | 37.9 ± 6.1 | 11.1 ± 3.7*** |
| Fore limb grip strength (grams-force) | 38.7 ± 2.6 | 51.2 ± 3.4** | 44.3 ± 3.4 | 50.5 ± 4.9** |
| Hind limb grip strength (grams-force) | 15.6 ± 1.6 | 23.9 ± 2.6** | 21.1 ± 0.9 | 25.8 ± 3.2** |
| Pole climbing down (sec) | 11.4 ± 2.3 | 11.8 ± 1.5 | 9.3 ± 0.9 | 13.4 ± 3.7 |
| Pole climbing up (sec) | 12.8 ± 2.7 | 26.1 ± 1.9*** | 9.7 ± 0.9 | 18.9 ± 5.3*** |
| Pole walking (sec) | 17.7 ± 3.9 | 19.6 ± 1.7 | 14.8 ± 3.6 | 16.0 ± 1.9 |
| 50% Withdrawal Threshold (Mechanical, grams-force) | 2.3 ± 1.3 | 1.0 ± 0.7** | 2.2 ± 1.5 | 1.7 ± 0.6** |
| Latency to Paw Flick (Thermal, sec) | 6.2 ± 1.0 | 6.5 ± 0.6 | 6.5 ± 0.2 | 6.9 ± 0.7 |
| Latency to Tail Flick (Themral, sec) | 4.3 ± 0.3 | 4.6 ± 0.5 | 4.7 ± 0.3 | 4.2 ± 0.7 |