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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Nat Rev Drug Discov. 2009 Jun;8(6):500–515. doi: 10.1038/nrd2828

Figure 1. The ‘Rosetta Stone approach‘ to drug development.

Figure 1

A crucial aspect of the proposed Rosetta Stone approach is the dynamic feedback from animal models and clinical data which can be used to identify treatments for drug addiction that are likely to succeed in clinical trials and to facilitate further development of animal and human models. These data may ultimately provide a rational basis for combination therapies such that multiple components of the addiction cycle can be treated by a given pharmacological strategy.