Figure 3.

Alignment of VHH amino-acid sequences (lysozyme and NOR binders) and of one vH human variable domain of heavy chain (POT vH). The hypervariable regions (CDR) are shown in red, green and blue. Residues substitutions are in pink, Cys residues involved in an intradomain (C22 and C92) are in orange, extra Cys residues possibly involved in an interloop disulfide bond are in purple. Kabat numbering is used.³⁴ [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]