Table 1. Compilation of miRNAs associated with angiogenesis.

miRNA	Cell type	miRNA target(s) (direct or indirect^*)	Function (by miRNA overexpression or inhibition) and putative role in angiogenesis	References
miR-221 miR-222	EC (HUVECs, EAhy 296) Prostate cancer cell lines	c-kit, eNOS^* p27/Kip1	Overexpression reduces tube formation, migration and wound healing (scratch assay) in response to SCF. ↓EC-mediated angiogenesis Induce proliferation and cell cycle progression. Inhibition reduces proliferation, increase p27 and reduces clonogenity of cells. ↑Tumor induced angiogenesis	¹⁸, ¹⁹ ⁸⁴

let-7f miR-27b	EC (HUVECs)	ND	Inhibition reduces in vitro sprout formation ↑EC-mediated angiogenesis	16

miR-126	EC (HUVECs, HAEC, mouse ECs)	Spred-1, PIK3R2/p85-β, VCAM-1	Inhibition increases TNF-induced expressionof VCAM-1 and leukocyte adhesion to ECs Regulates vascular integrity and angiogenesis in miR-126 knockdow zebrafish and miR-126^-/- mice. Inhibition reduces tube formation, sprout formation, wound healing (scratch assay) and proliferation in response to VEGF and FGF. ↑EC-mediated angiogenesis	17, 22, 85

miR-130a	EC (HUVECs)	GAX, HOXA5	Overexpression antagonized the inhibitory effect of GAX on EC proliferation, migration and tube formation and the inhibitory effects of HoxA5 on tube formation ↑EC-mediated angiogenesis	107

miR-210	EC (HUVECs) Breast and colon cancer cell lines, nasopharyngeal carcinoma cell line, head and squamous cell carcinoma	EphrinA3 ND	Stimulated by hypoxia. Overexpression stimulates tube formation and migration. ↑EC-mediated angiogenesis Stimulated by hypoxia. decrease proapoptotic signaling in a hypoxic environment. ↑Tumor induced angiogenesis	¹⁰⁸ ¹¹⁰, ¹¹¹

miR-15 miR-16	Nasopharyngeal carcinoma cell line Chronic lymphocytic leukemia (CLL) Colon cancer cells	VEGF, Bcl2	Downregulated by hypoxia. Overexpression induces apoptosis in leukemic cell line model. Cell cycle regulation. Inhibition reduces number of cells G0/G1 promoting cell cycle progression. ↓Tumor induced angiogenesis	111, 115, 116

miR-378	Glioblastoma cells	Sufu, Fus-1	Overexpression promotes cell survival tumur growth and angiogenesis in vivo. ↑Tumor induced angiogenesis	140

miR-17-92 cluster	EC (HUVECs) Malignant lymphoma cells, Colorectal cancer cells, NSCLC Lymphocytes	Tsp-1 (miR-18a) E2F1 (miR-17-5p / miR-20a) CTGF (miR-18a, Tsp-1 (miR-19) PTEN, Bim	Stimulated by VEGF. Overexpression promotes cell proliferation and cord formation converse effects by inhibition. ↑EC-mediated angiogenesis Expression control by c-Myc and E2F. Promote cell proliferation and survival. Overexpression in colonocytes form larger and better-perfused tumors in vivo. ↑Tumor induced angiogenesis Overexpression contributes lymphoproliferative disease.	²⁰ ¹⁰¹, ¹²⁰, ¹²², ¹²³ ¹²⁷

miR-296	EC (human brain microvascular ECs)	HGS	Stimulated by glioma cells and angiogenic factors (EGF, VEGF). Inhibition reduces tube formation and migration (scratch assay) in vitro and angiogenesis in tumor xenografts in vivo. ↑EC-mediated and tumor induced angiogenesis	109

miR-155	EC, VSMC, Fibroblast Breast cancer cells, malignant lymphoma cells, NSCLC Lymphocytes, macrophages	AT1R ND ND	Inhibtion increases AT1R expression and Ang II-induced ERK1/2 activation. ?EC-mediated angiogenesis Required for normal immune and imflammatory responses	⁹⁵, ¹⁴¹ ⁹⁷, ¹²¹, ¹²²,¹⁴², ¹⁴³

ND= not determined