Table 1.
Characteristics of the study population
| Characteristic | CYP3A5 expressors (n = 15) | Non-expressors (n = 16) | P |
|---|---|---|---|
| CYP3A5 genotype (n) | *1*3 (9); *1*1 (4); *1*7 (1); *1*6 (1) | *3*3 (13); *7*7 (2); *1*3 and *1*7 (1)a | — |
| African-American | 7 (3 female) | 6 (4 female) | — |
| Non-African-American | 8 (4 female) | 10 (5 female) | — |
| Hispanic | 3 | 1 | |
| Asian | 1 | 0 | |
| Caucasian | 4 | 9 | |
| UGT1A1 *28 (n) | *1/*1 (5); *1/*28 (6); *28/*28 (4) | *1/*1 (5); *1/*28 (10); *28/*28 (1) | — |
| ABCB1 CGC copies, i.e. 1236C, 2677G and 3435C (n) | 0 copies (5); 1 copy (6); 2 copies (4) | 0 copies (6); 1 copy (7); 2 copies (3) | — |
| Age, years (median, range) | 30 (20–44) | 32 (24–51) | 0.12 |
| Weight, kg (median, range) | 73 (50–97) | 75 (55–106) | 0.78 |
| BMI (median, range) | 25.4 (19.1–31.7) | 24.6 (19.3–28.5) | 0.77 |
aComputational haplotype analysis showed >80% probability that this subject was a non-expressor (see text).