Table 2.
Tissue distribution of AdhAQP1 in rats administered 2 × 1011 vector genomes in the right submandibular gland
| Tissue | Day 3 | Day 29 | Day 92 |
|---|---|---|---|
| Left parotid | 0/10 | 0/10 | 0/10 |
| Left SMG | 4/10 | 1/10 | 3/10 |
| Left SLG | 0/10 | 0/10 | 1/10 |
| Left mandibular lymph node | 1/10 | 0/10 | 1/10 |
| Right parotid | 1/10 | 0/10 | 0/10 |
| Right SMG | 9/10 | 4/10 | 4/10 |
| Right SLG | 2/10 | 3/10 | 7/10 |
| Right mandibular lymph node | 2/10 | 0/10 | 1/10 |
| Buccal mucosa | 0/10 | 0/10 | 0/10 |
| Floor-of-mouth mucosa | 3/10 | 0/10 | 0/10 |
| Palatal mucosa | 0/10 | 0/10 | 0/10 |
| Tongue | 0/10 | 0/10 | 0/10 |
| Brain | 0/10 | 0/10 | 0/10 |
| Spleen | 2/10 | 0/10 | 1/10 |
| Liver | 1/10 | 0/10 | 0/10 |
| Lung | 2/10 | 0/10 | 0/10 |
| Kidney | 0/10 | 0/10 | 0/10 |
| Gonads | 0/10 | 0/10 | 0/10 |
| Blood | 0/10 | 0/10 | 0/10 |
| Saliva | 1/10 | 0/10 | 0/10 |
This table is modified from Table 2 of (Zheng et al. 2006). The data shown come from PCR-necropsies of experimental animals and represent the number of real time PCR-positive samples per total number of samples assayed. The target gland was the right submandibular gland, and these data are shown in italics. As is clear from the data, when the AdhAQP1 vector was administered to a single gland most of the vector was localized to that gland, and very little was found outside adjacent oral tissues