Figure 1. Activity of compounds in pheophorbide a screening assay.
The compounds listed were assayed for their ability to cause ABCG2-overexpressing cells (NCI-H460/MX20 cells) to accumulate PhA. Each compound was tested at 10 μM (final concentration - bars) and, after resupply, in a dose-response format. Activity for each compound was normalized to the response of 10 μM FTC control wells on the same plate. Error bars represent se (n = 7-9). IC50 values are averages of duplicate determinations for each dose.