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Involvement of RYs in the generation of Ca2+ spikes in glucose-stimulated beta cells. [Ca2+]i was measured in fura-2 loaded cells perifused by the basal medium. Addition of forskolin (5 μM) to glucose-stimulated beta cells induced a few Ca2+ spikes. Forskolin-induced Ca2+-spikes were further enhanced by 3,9-DMX in all of the eight cells examined.
