Figure 3.

Effect of glycosylation on MHC binding. Binding of peptides derived from SwissProt/UniProtKB entries with SigP to the most common human HLA II alleles was predicted by NetMHCII software. A. HLA alleles showed significant differences in the numbers of predicted binding peptides. B. Proportion of peptides predicted to carry an N-glycosylation site is very different among different MHC II molecules. Most HLA DR alleles are found to be more prone tolerate N-glycosylation, than HLA DP and DQ. C. The frequency of probable O-glycosylation among peptides binding to different HLA alleles is shown on a polar graph.