Figure 4.

Number of N-glycosylation sites in autoantigens and non-autoantigenic proteins. Human SwissProt/UniProtKB proteins and known autoantigens (Autoantigen Database) with SigP were examined for the number of probable N-glycosylation sites. For each protein, random control sequences (n = 5) were generated consisting of the same amino acids and of the same length. The mean number of glycosylation sites found in random control sequences was subtracted from the number found in the given protein. The frequency of the difference values is shown for both the autoantigenic and the non-autoantigenic proteins.