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Identification of hot-spots for mutations that may increase A/H1N1/-receptor interaction. (a) Effect of alanine substitution on the amplitude at frequency F(0.295). "In silico" alanine scan of the complete HA1 sequence of the early A/H1N1 isolate A/Mexico/4115/2009 (EPI177288). (b) Homology between HA1 of A/Castilla-La Mancha/GP13/2009 (FJ985753) (identical to US isolate A/South Carolina/09/2009), swine H1N1 viruses infecting human 2005-2007 and A/Mexico/4115/2009 (EPI177288).
