Table 5.

Ingenuity Pathways Analysis: Top Bio Functions - Physiological System Development and Function

Category	P-value*	Molecules	N°
Connective Tissue Development and Function	2.14E-04 to 3.06E-02	RPL22, ICAM1, LIF, KLF10, BMP2, MMP14, METTL8, HAX1, TNFAIP3, NFKB1, MSX2, EIF4EBP1, PTEN, PGF, LIMK1, EDN1, CHST3, FOSL2, SSBP3, MMP1 (includes EG:4312), SRC, PXN, MITF, BGN, JUNB, IRAK3, CEBPB, NFKB2, IGF2R, NDN, NOV, RUNX1, PLAU	33
Embryonic Development	2.14E-04 to 3.06E-02	LIF, ICAM1, BMP2, EXT1, NUP50, MSX2, PTEN, NR4A3, NFKBIA, RASSF1, EDN1, POSTN, FOSL2, SRC, PXN, MITF, FGFR1, THRA, L1CAM, JUNB, CEBPB, AFF1, BTG2, RBPJ, IFT52, PLAU	26
Skeletal and Muscular System Development and Function	2.14E-04 to 3.06E-02	MSC, VAMP5, LIF, MMP14, BMP2, KLF10, METTL8, FKBP1A, EXT1, NFKB1, COMP, MSX2, PGF, PTEN, SATB2, NFKBIA, EDN1, CDON, FOXO3, CHST3, POSTN, FOSL2, ACTC1, SSBP3, CACNA1G, SRC, NOX4, BMP2K (includes EG:55589), NAB1, SGCG, MITF, FGFR1, BGN, ADCY3, THRA, NFKB2, IRAK3, JUNB, SMA4, RBPJ, PLAU, RUNX1	42
Tissue Morphology	2.14E-04 to 3.06E-02	ICAM1, LIF, BMP2, NFKB1, MSX2, ABCA1, PGF, PTEN, EIF4EBP1, CASP9, NFKBIA, EDN1, CTSS, PHGDH, FOSL2, SSBP3, SRC, RELB, BGN, ZIC1, APAF1, L1CAM, THRA, JUNB, NFKB2, CEBPB, OGG1, AFF1, CCND2, RBPJ, CYLD, PLAU, ATP2B4	33
Respiratory System Development and Function	1.44E-03 to 3.06E-02	SRC, NFKBIA, CCND2, COX11, EDN1, MAN2A1, MAFB, ABCA1, NDN, PTEN	10

*Fischer's exact test was used to calculate a p-value determining the probability that each biological function assigned to that data set is due to chance alone.