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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Gene. 2009 Aug 13;448(1):74–87. doi: 10.1016/j.gene.2009.08.003

Table 2.

a. Amino acid identity of bHLH-PAS and HES genes between beetle and fruitfly; beetle and vertebrates
bHLH gene Fly homologue Vertebrate homologue % Overall identify % HLH identity % Overall identity % HLH identity
TcHairy DmHairy HsHES-1 45 89 39 83
TcSide2 DmSide HsHES1 24 62 20 55
TcDeadpan DmDeadpan HsHES-1 32 90 29 77
TcE(spl)mgamma2 DmE(spl)mgamma HsHES-4 42 81 26 62
TcE(spl)mgamma1 DmE(spl)mgamma HsHES-1 45 90 30 62
TcSide1 DmSide HsHES-1 35 83 29 65
TcHey1 DmHey1 HsHey1 16 88 38 88
TcHey2 DmHey2 HsHey2 32 87 38 88
TcSRC DmTaiman HsSRC 14 48 17 71
TcTango DmTango HsARNT 58 100 49 93
TcCycle DmCycle HsCycle 41 91 30 74
TcClock DmClock HsClock 45 81 33 62
TcTrachealess DmTrachealess HsNPAS 42 98 24 93
TcSim1 DnSim HsSim 48 93 41 91
TcSim2 DmSim HsSim 33 93 21 91
TcHypoxia DmHypoxia HsHIF 25 68 26 70
TcSpineless DmSpineless HsAhr 57 67 26 65
TcDysfusion DmDysfusion HsNXF 68 78 28 31
TcMet/GCE DmGCE/Met - 24/25 53/51 - -
b. Amino acid identity of Myc/USF, Hand, Shout, p48, NeuroD/Neurogenin, Atonal, AS-C and miscellaneous genes between beetle and fruitfly; beetle and vertebrates
bHLH Name Fly homologue Vertebrate homologue % Overall identity % HLH identity % Overall identity % HLH identity
TcHLH106 DmHLH106 HsSREBP2 29 77 29 69
TcBigmax DmBigmax HsBigmax 43 90 52 82
 TcAP-4 DmAP-4 HsAP-4 30 86 31 89
TcMax DmMax HsMax 47 56 51 87
TcMyc DmMyc HsMyc 17 64 13 51
TcMnt DmMnt HsMnt 18 65 21 78
TcFlocculin like - - - - - -
TcUSF2 DmUSF2 HsUSF 17 65 21 78
TcHLH3B DmHLH3B HsSCL 21 82 21 75
TcTwist DmTwist HsTwist 31 79 40 92
TcHand DmHand HsHand 42 75 38 79
TcTF21 DmHLH54F HsTF21 39 55 41 89
TcParaxis DmParaxis HsParaxis 31 60 38 82
TcDelilah2 DmDelilah HsNDF6 33 79 22 56
TcDelilah1 DmDelilah HsNEUROD2 33 76 22 61
TcShout DmNet HsATOH8 33 58 25 56
TcFer3 DmFer3 HsFer3 43 92 53 90
TcFer2 DmFer2 MdFer2 70 86 52 91
TcFer1 DmFer1 HsPTF1 40 54 35 56
TcDimmed DmDimmed HsMIST1 37 67 29 62
TcTap DmTap HsNEUROG2 29 76 27 79
TcNeuroD - HsNeuroD1 31 79
TcBeta3 DmBeta3 HsBeta3 46 96 35 98
TcHLH4C DmNHLH1 HsNHLH1 46 94 54 95
TcNautilus DmNautilus HsMyf5 40 62 35 55
TcCato DmCato HsATOH1 35 72 34 77
TcAtonal DmAtonal HsATOH1 53 85 40 67
TcAmos DmAmos HsATOH1 38 77 33 74
TcScute DmScute HsMash-3 26 50 28 53
TcAsense DmAsense HsMash-3 32 82 15 46
TcAsh DmAcheate HsASH1 32 71 26 72
TcDaughterless DmDaughterless HsTCF12 33 87 22 69
TcEmc DmEmc - 37 76
TcMitf DmMitf HsMitf 39 96 29 80