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. Author manuscript; available in PMC: 2010 Nov 15.
Published in final edited form as: J Neurol Sci. 2009 May 13;286(1-2):81–85. doi: 10.1016/j.jns.2009.04.023

Figure 3.

Figure 3

ERβ ligand treatment results in recovery of motor function in EAE.

(a) Mean time on rotarod decreased abruptly at day 12 after disease induction in both the vehicle and DPN treated EAE mice. But after day 30 the DPN treated group demonstrated significant recovery of motor function, while the vehicle treated did not improve. Estradiol treatment served as a positive control for a treatment effect. (b) In contrast to the improvement observed with DPN treatment of wild type mice, no improvement was observed at the later phase of disease in DPN treated ERβ KO mice(21).