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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: J Mol Recognit. 2009 Nov-Dec;22(6):495–505. doi: 10.1002/jmr.972

Figure 1.

Figure 1

Structure of compstatin and its analogs. (A) The core structure of compstatin is comprised of a cyclic tridecapeptide. (The structure shown represents peptide 4W in Table 1.) In the present study, changes were made to residues 4, 6, and 9 (Table 1) by introducing several natural (P, W, Y) and the following unnatural amino acids: (b) O-methyl-tyrosine (MeY), (c) O-ethyl-tyrosine (EtY), (d) O-allyl-tyrosine (AlY), (e) 5-methyl-tryptophan (5MeW), (f) 2-naphthyl-alanine (2Nal), (g) 1-methyl-tryptophan (1MeW), (h) 1-formyl-tryptophan (1ForW), (i) 4-pyrenyl-alanine (PyrA), (j) iso-aspartic acid (IsoD), (k) α-aminobutyric acid (Abu).