Table 2. Association of antibody titers to individual rotavirus proteins and resistance to infection and diarrhea in adult volunteers.
Antibody Isotype | Rotavirus | Likelihood Ratio p valuea | ||
---|---|---|---|---|
Protein | Strain (Specificity) | |||
Pre-challenge | ||||
IgG | VP7 | D(G1) | 0.0077 | |
VP7 | DS-1 (G2) | |||
VP7 | P(G3) | 0.0130 | ||
VP7 | ST3 (G4) | |||
VP7 | AU32 (G9) | |||
VP4 | KU (P1A[8]) | 0.0091 | ||
VP4 | DS-1 (P1B[4]) | |||
VP4 | 1076 (P2A[6]) | 0.0191 | ||
VP4 | 69M(P4[10]) | |||
NSP4 | DS-1 ([A]) | 0.0100 | ||
| ||||
IgA | VP7 | D(G1) | 0.0316 | |
NSP4 | SA11 ([A]) | 0.0363 | ||
| ||||
Post-challenge | ||||
IgG | VP7 | D(G1) | 0.0140 | |
VP7 | DS-1 (G2) | 0.0291 | ||
NSP4 | SA11 ([A]) | 0.0363 | ||
| ||||
IgA | VP7 | D(G1) | 0.0003 | |
VP7 | DS-1 (G2) | 0.0209 | ||
VP7 | AU32 (G9) | 0.0209 | ||
VP4 | KU (P1A[8]) | 0.0483 |
Note: Logistic regression analyses were performed to estimate probability of resistance to rotavirus infection with antibody titers to individual viral proteins.
a Likelihood ratio test p values. Smaller p value indicates strong signicant association of resistance to rotavirus infection. P values >0.05 are not shown. P values <0.01 are in boldface.