Table 1.
Type assignment for all 50 families of ABC efflux systems identified and listed in TCDBa
| TC number | Family name | Known substrate range | ABC type |
|---|---|---|---|
| 3.A.1.101 | Capsular polysaccharide exporter (CPSE) | CPS | 2 |
| 3.A.1.102 | Lipooligosaccharide exporter (LOSE) | LOS | 2 |
| 3.A.1.103 | Lipopolysaccharide exporter (LPSE) | LPS | 2 |
| 3.A.1.104 | Techoic acid exporter (TAE) | TA | 2 |
| 3.A.1.105 | Drug exporter-1 (DrugE1) | Drugs | 2 |
| 3.A.1.106 | Lipid exporter (LipidE) | PL, LPS, lipid A, drugs, peptides | 1 |
| 3.A.1.107 | Putative heme exporter (HemeE) | Heme, cytochrome c | 2 |
| 3.A.1.108 | ß-Glucan exporter (GlucanE) | Polysaccharides | 1 |
| 3.A.1.109 | Protein-1 exporter (Prot1E) | Proteins | 1 |
| 3.A.1.110 | Protein-2 exporter (Prot2E) | Proteins | 1 |
| 3.A.1.111 | Peptide-1 exporter (Pep1E) | Bacteriocin, peptides | 1 |
| 3.A.1.112 | Peptide-2 exporter (Pep2E) | Other peptides | 1 |
| 3.A.1.113 | Peptide-3 exporter (Pep3E) | Antibiotics, siderophores | 1 |
| 3.A.1.114 | Probable glycolipid exporter (DevE) | Glycolipids | 3 |
| 3.A.1.115 | Na+ exporter (NatE) | Sodium | 2 |
| 3.A.1.116 | Microcin B17 exporter (McbE) | Bacteriocins, peptides | 2 |
| 3.A.1.117 | Drug exporter-2 (DrugE2) | Drugs, lipids, dyes | 1 |
| 3.A.1.118 | Microcin J25 exporter (McjD) | Peptides, antibiotics | 1 |
| 3.A.1.119 | Drug/siderophore exporter-3 (DrugE3) | Drugs, siderophores | 1 |
| 3.A.1.120 | (Putative) Drug resistance ATPase-1 (DrugRA1) | Drugs | b |
| 3.A.1.121 | (Putative) Drug resistance ATPase-2 (DrugRA2) | Drugs, antibiotics | b |
| 3.A.1.122 | Macrolide exporter (MacB) | Macrolides, heme | 3 |
| 3.A.1.123 | Peptide-4 exporter (Pep4E) | Drugs, peptides | 1 |
| 3.A.1.124 | 3-Component peptide-5 exporter (Pep5E) | Bacteriocins | 2 |
| 3.A.1.125 | Lipoprotein translocase (LPT) | O.M. Lipoproteins | 3 |
| 3.A.1.126 | ß-Exotoxin I exporter (ß-ETE) | Proteins | 2 |
| 3.A.1.127 | AmfS peptide exporter (AmfS-E) | Peptides, morphogens | 2 |
| 3.A.1.128 | SkfA peptide exporter (SkfA-E) | Modified peptides | 2 |
| 3.A.1.129 | CydDC cysteine exporter (CydDC-E) | Cysteine | 1 |
| 3.A.1.130 | Multidrug/hemolysin exporter (MHE) | Drugs, hemolysins | 2 |
| 3.A.1.131 | Bacitracin resistance (Bcr) | Bacteriocins | 2 |
| 3.A.1.132 | Gliding motility ABC transporter (Gld) | Polysaccharides, copper ions | 2 |
| 3.A.1.133 | Peptide-6 exporter (Pep6E) | Peptides | 2 |
| 3.A.1.134 | Peptide-7 exporter (Pep7E) | Peptides, bacteriocins | 3 |
| 3.A.1.135 | Drug exporter-4 (DrugE4) | Drugs | 1 |
| 3.A.1.136 | Uncharacterized ABC3-type (U-ABC3-1) | Unknown | 3 |
| 3.A.1.137 | Uncharacterized ABC3-type (U-ABC3-2) | Unknown | 3 |
| 3.A.1.138 | Unknown ABC2-type (ABC2-1) | Unknown | 2 |
| 3.A.1.201 | Multidrug resistance exporter (MDR) | Drugs, fatty acids, lipids | 1 |
| 3.A.1.202 | Cystic fibrosis transmembrane exporter (CFTR) | Chloride | 1 |
| 3.A.1.203 | Peroxysomal fatty acyl CoA transporter (P-FAT) | Long chain fatty acids | 1 |
| 3.A.1.204 | Eye pigment precursor transporter (EPP) | Pigments, drugs, hemes | 2 |
| 3.A.1.205 | Pleiotropic drug resistance (PDR) | Drugs, steroids, nucleotides, acids | 2 |
| 3.A.1.206 | a-Factor sex pheromone exporter (STE) | Peptides | 1 |
| 3.A.1.207 | Eukaryotic ABC3 (E-ABC3) | Unknown | 3 |
| 3.A.1.208 | Drug conjugate transporter (DCT) | Drugs, conjugates, anions, peptides, folates | 1 |
| 3.A.1.209 | MHC peptide transporter (TAP) | Peptides | 1 |
| 3.A.1.210 | Heavy metal transporter (HMT) | Drugs, metal conjugates, heme | 1 |
| 3.A.1.211 | Cholesterol/phospholipid/retinal (CPR) flippase | Drugs, sterols, lipids, retinal, surfactants, proteins, peptides, xenobiotics | 2 |
| 3.A.1.212 | Mitochondrial peptide exporter (MPE) | Peptides | 1 |
aTC number within the ABC superfamily (3.A.1) is provided in the first column. The family name is given in the second column, with the family abbreviation presented in parentheses. Column 3 indicates the substrates known to be transported, while column 4 indicates to which topological type family members belong
bThe membrane constituents of these two families of putative ABC drug export systems have not been identified