Table 1.
Age-adjusted ORs and 95% CIs for CYP19A1 genotypes and risk of breast cancer and fibrocystic conditions, by proliferative status
| Breast cancer | Fibrocystic conditions | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls | All | With non-proliferative fibrocystic conditions |
With proliferative fibrocystic conditions |
All | Non-proliferative | Proliferative | |||||||||||||
| n | n | OR | 95% CI | n | OR | 95% CI | n | OR | 95% CI | n | OR | 95% CI | n | OR | 95% CI | n | OR | 95% CI | |
| Block 1 SNPs | |||||||||||||||||||
| rs1870049 | |||||||||||||||||||
| TT | 548 | 371 | 1.00 | (ref) | 75 | 1.00 | (ref) | 67 | 1.00 | (ref) | 278 | 1.00 | (ref) | 99 | 1.00 | (ref) | 117 | 1.00 | (ref) |
| CT | 292 | 211 | 1.06 | (0.85–1.33) | 44 | 1.08 | (0.73–1.62) | 41 | 1.14 | (0.75–1.72) | 154 | 1.05 | (0.82–1.35) | 44 | 0.85 | (0.58–1.25) | 55 | 0.90 | (0.63–1.29) |
| CC | 38 | 30 | 1.18 | (0.72–1.94) | 5 | 1.02 | (0.39–2.69) | 8 | 1.78 | (0.79–3.98) | 32 | 1.48 | (0.89–2.43) | 11 | 1.38 | (0.68–2.82) | 10 | 1.12 | (0.54–2.33) |
| rs1004982 | |||||||||||||||||||
| TT | 410 | 291 | 1.00 | (ref) | 61 | 1.00 | (ref) | 44 | 1.00 | (ref) | 208 | 1.00 | (ref) | 75 | 1.00 | (ref) | 81 | 1.00 | (ref) |
| CT | 371 | 245 | 0.92 | (0.74–1.15) | 51 | 0.90 | (0.60–1.34) | 48 | 1.18 | (0.77–1.82) | 193 | 1.05 | (0.82–1.34) | 58 | 0.89 | (0.61–1.30) | 79 | 1.11 | (0.79–1.57) |
| CC | 90 | 72 | 1.13 | (0.80–1.60) | 12 | 0.93 | (0.48–1.80) | 21 | 2.19 | (1.24–3.85) | 63 | 1.31 | (0.91–1.90) | 21 | 1.21 | (0.70–2.08) | 21 | 1.15 | (0.67–1.97) |
| Block 2 SNPs | |||||||||||||||||||
| rs28566535 | |||||||||||||||||||
| AA | 404 | 278 | 1.00 | (ref) | 55 | 1.00 | (ref) | 45 | 1.00 | (ref) | 203 | 1.00 | (ref) | 73 | 1.00 | (ref) | 80 | 1.00 | (ref) |
| AC | 370 | 259 | 1.01 | (0.81–1.26) | 59 | 1.14 | (0.77–1.70) | 45 | 1.08 | (0.70–1.67) | 203 | 1.10 | (0.86–1.41) | 63 | 0.97 | (0.67–1.40) | 84 | 1.18 | (0.84–1.66) |
| CC | 94 | 71 | 1.09 | (0.78–1.54) | 11 | 0.87 | (0.44–1.72) | 23 | 2.20 | (1.27–3.82) | 55 | 1.10 | (0.75–1.61) | 18 | 1.01 | (0.57–1.77) | 17 | 0.89 | (0.50–1.58) |
| rs936306 | |||||||||||||||||||
| CC | 405 | 279 | 1.00 | (ref) | 58 | 1.00 | (ref) | 49 | 1.00 | (ref) | 205 | 1.00 | (ref) | 75 | 1.00 | (ref) | 80 | 1.00 | (ref) |
| CT | 368 | 257 | 1.01 | (0.81–1.26) | 54 | 1.00 | (0.67–1.48) | 42 | 0.93 | (0.60–1.44) | 208 | 1.15 | (0.90–1.47) | 59 | 0.91 | (0.62–1.32) | 87 | 1.24 | (0.88–1.74) |
| TT | 102 | 77 | 1.09 | (0.78–1.52) | 13 | 0.88 | (0.47–1.68) | 24 | 1.94 | (1.13–3.30) | 52 | 0.99 | (0.67–1.44) | 20 | 1.04 | (0.60–1.79) | 15 | 0.74 | (0.41–1.35) |
| Block 3 SNP | |||||||||||||||||||
| rs11636639 | |||||||||||||||||||
| GG | 244 | 173 | 1.00 | (ref) | 34 | 1.00 | (ref) | 31 | 1.00 | (ref) | 131 | 1.00 | (ref) | 44 | 1.00 | (ref) | 51 | 1.00 | (ref) |
| GT | 410 | 289 | 1.00 | (0.78–1.28) | 54 | 0.97 | (0.61–1.53) | 59 | 1.14 | (0.71–1.80) | 213 | 0.94 | (0.72–1.24) | 65 | 0.87 | (0.57–1.32) | 89 | 1.03 | (0.70–1.50) |
| TT | 198 | 140 | 1.01 | (0.75–1.35) | 32 | 1.24 | (0.74–2.10) | 25 | 1.02 | (0.58–1.80) | 110 | 0.97 | (0.70–1.34) | 40 | 1.07 | (0.67–1.72) | 38 | 0.87 | (0.55–1.39) |
| Block 4 SNPs | |||||||||||||||||||
| rs767199 | |||||||||||||||||||
| AA | 185 | 126 | 1.00 | (ref) | 31 | 1.00 | (ref) | 17 | 1.00 | (ref) | 97 | 1.00 | (ref) | 36 | 1.00 | (ref) | 34 | 1.00 | (ref) |
| AG | 438 | 294 | 0.98 | (0.75–1.28) | 57 | 0.76 | (0.47–1.21) | 59 | 1.45 | (0.82–2.55) | 219 | 0.98 | (0.72–1.32) | 68 | 0.83 | (0.53–1.29) | 88 | 1.12 | (0.72–1.73) |
| GG | 255 | 191 | 1.10 | (0.82–1.47) | 37 | 0.86 | (0.51–1.44) | 38 | 1.61 | (0.88–2.94) | 149 | 1.13 | (0.82–1.57) | 50 | 1.02 | (0.63–1.63) | 60 | 1.32 | (0.83–2.10) |
| rs4775936 | |||||||||||||||||||
| TT | 174 | 114 | 1.00 | (ref) | 27 | 1.00 | (ref) | 16 | 1.00 | (ref) | 100 | 1.00 | (ref) | 36 | 1.00 | (ref) | 38 | 1.00 | (ref) |
| CT | 459 | 302 | 1.00 | (0.76–1.32) | 52 | 0.71 | (0.43–1.16) | 55 | 1.28 | (0.71–2.30) | 221 | 0.86 | (0.64–1.16) | 65 | 0.71 | (0.46–1.12) | 89 | 0.92 | (0.61–1.41) |
| CC | 243 | 196 | 1.23 | (0.91–1.66) | 46 | 1.21 | (0.72–2.02) | 44 | 1.95 | (1.07–3.58) | 144 | 1.03 | (0.74–1.43) | 53 | 1.03 | (0.64–1.66) | 55 | 1.05 | (0.66–1.66) |
| rs11575899 | |||||||||||||||||||
| INS/INS | 453 | 309 | 1.00 | (ref) | 66 | 1.00 | (ref) | 57 | 1.00 | (ref) | 247 | 1.00 | (ref) | 81 | 1.00 | (ref) | 92 | 1.00 | (ref) |
| INS/DEL | 358 | 252 | 1.03 | (0.83–1.28) | 52 | 1.01 | (0.68–1.49) | 45 | 1.01 | (0.66–1.52) | 174 | 0.87 | (0.68–1.11) | 57 | 0.87 | (0.60–1.26) | 71 | 0.96 | (0.68–1.35) |
| DEL/DEL | 65 | 50 | 1.14 | (0.76–1.69) | 7 | 0.76 | (0.34–1.74) | 12 | 1.50 | (0.76–2.95) | 42 | 1.12 | (0.73–1.72) | 15 | 1.21 | (0.65–2.24) | 18 | 1.25 | (0.71–2.23) |
| rs10046 | |||||||||||||||||||
| TT | 277 | 178 | 1.00 | (ref) | 46 | 1.00 | (ref) | 30 | 1.00 | (ref) | 152 | 1.00 | (ref) | 55 | 1.00 | (ref) | 54 | 1.00 | (ref) |
| CT | 436 | 308 | 1.10 | (0.86–1.39) | 52 | 0.71 | (0.47–1.09) | 67 | 1.41 | (0.89–2.22) | 210 | 0.88 | (0.67–1.14) | 62 | 0.72 | (0.48–1.07) | 84 | 0.99 | (0.68–1.45) |
| CC | 163 | 125 | 1.19 | (0.88–1.61) | 27 | 1.01 | (0.60–1.69) | 17 | 0.97 | (0.52–1.81) | 99 | 1.08 | (0.78–1.50) | 34 | 0.99 | (0.62–1.60) | 43 | 1.34 | (0.86–2.10) |
| rs4646 | |||||||||||||||||||
| GG | 441 | 298 | 1.00 | (ref) | 64 | 1.00 | (ref) | 56 | 1.00 | (ref) | 240 | 1.00 | (ref) | 81 | 1.00 | (ref) | 87 | 1.00 | (ref) |
| GT | 358 | 260 | 1.08 | (0.87–1.34) | 53 | 1.04 | (0.70–1.53) | 50 | 1.10 | (0.73–1.65) | 177 | 0.89 | (0.70–1.14) | 57 | 0.85 | (0.59–1.24) | 72 | 1.01 | (0.71–1.42) |
| TT | 77 | 53 | 1.03 | (0.70–1.50) | 8 | 0.75 | (0.34–1.62) | 8 | 0.83 | (0.38–1.82) | 45 | 1.03 | (0.68–1.54) | 14 | 0.92 | (0.49–1.72) | 22 | 1.36 | (0.80–2.32) |